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mTOR signaling pathway

雷帕霉素mTOR可对细胞外相关因子刺激万博官网登陆应答,包括生长因子、胰岛素、营养素、氨基酸及葡萄糖。在哺乳动物中,是一种高保守的丝氨酸苏氨酸万博官网登陆激酶。如下图所示,mTOR有两种复合物存在形式,mTORC1和mTORC2。mTORC1由 mTOR、Raptor、PRAS40、Deptor、mLST8、Tel2和Tti1组成,一般对生长因子、氨基酸、氧化应激和机能状态转变刺激产生应答,涉及脂代谢、自噬、万博官网登陆合成和核小体生物合成等多个生物过程。mTORC2,由mTOR,mSin1,Rictor,Protor,Deptor,mLST8,Tel2和Tti1组成,主要应答生长因子刺激,调控细胞骨架组织及代谢。mTOR主要是通过PI3K/Akt/mTOR途径来实现对细胞生长、细胞周期等多种生理功能的调控作用。

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